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4-Methylpyridin-2-amine

CAS No.
695-34-1
Chemical Name:
4-Methylpyridin-2-amine
Synonyms
2-AMINO-4-METHYLPYRIDINE;2-AMINO-4-PICOLINE;Aminopicoline;w45;W 45;4M2AP;ra1226;RA 1226;NSC 1490;NSC 6972
CBNumber:
CB9854129
Molecular Formula:
C6H8N2
Molecular Weight:
108.14
MDL Number:
MFCD00149166
MOL File:
695-34-1.mol
MSDS File:
SDS
Last updated:2024-05-10 09:59:16

4-Methylpyridin-2-amine Properties

Melting point 96-99 °C (lit.)
Boiling point 230 °C (lit.)
Density 1.0275 (estimate)
vapor pressure 3.71Pa at 25℃
refractive index 1.5560 (estimate)
Flash point 118 °C
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility DMF: freely soluble
form Flakes
pka pK1: 7.48(+1) (25°C)
color Slightly yellow to beige or brown
Water Solubility SOLUBLE
Sensitive Hygroscopic
Merck 14,466
BRN 107066
LogP 0.56-1.08
CAS DataBase Reference 695-34-1(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 394N1Z644H
NIST Chemistry Reference 2-Pyridinamine, 4-methyl-(695-34-1)
EPA Substance Registry System 2-Pyridinamine, 4-methyl- (695-34-1)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS06,GHS08
Signal word  Danger
Hazard statements  H301+H311+H331-H373
Precautionary statements  P280-P301+P310+P330-P302+P352+P312-P304+P340+P311-P314
Hazard Codes  T
Risk Statements  45-46-60-61-8-21-25-26-34-42/43-48/23-50/53-36/37/38-33-23/24/25
Safety Statements  53-45-60-61-37/39-28A-26-36/37/39
RIDADR  UN 3086 6.1/PG 1
WGK Germany  3
RTECS  TJ5150000
TSCA  Yes
HazardClass  6.1
PackingGroup  II
HS Code  29333999
Toxicity LD50 oral in rat: 200mg/kg
NFPA 704
1
3 1

4-Methylpyridin-2-amine price More Price(37)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 123080 2-Amino-4-methylpyridine 99% 695-34-1 100g $59.9 2024-03-01 Buy
TCI Chemical A0402 2-Amino-4-methylpyridine >98.0%(GC)(T) 695-34-1 25g $65 2024-03-01 Buy
TCI Chemical A0402 2-Amino-4-methylpyridine >98.0%(GC)(T) 695-34-1 500g $390 2024-03-01 Buy
Alfa Aesar A14177 2-Amino-4-methylpyridine, 98% 695-34-1 25g $22.65 2024-03-01 Buy
Alfa Aesar A14177 2-Amino-4-methylpyridine, 98% 695-34-1 100g $32.65 2024-03-01 Buy
Product number Packaging Price Buy
123080 100g $59.9 Buy
A0402 25g $65 Buy
A0402 500g $390 Buy
A14177 25g $22.65 Buy
A14177 100g $32.65 Buy

4-Methylpyridin-2-amine Chemical Properties,Uses,Production

Chemical Properties

Light yellow to brown flakes

Uses

Intermediate, medicine.

Uses

2-Amino-4-methylpyridine has been used in the synthesis of 2-amino-4-methyl-pyridinium 2-hy-droxy-benzoate. It is potent inhibitor of NOS2 (iNOS) in vitro. It is used as pharmaceutical intermediate.

Synthesis Reference(s)

The Journal of Organic Chemistry, 72, p. 4554, 2007 DOI: 10.1021/jo070189y

General Description

2-Amino-4-methylpyridine acts as ligand and forms methoxo-bridged copper(II) complexes.

Biochem/physiol Actions

2-Amino-4-methylpyridine inhibits the activity of inducible NO synthase isolated from mouse RAW 264.7 cells in vitro.

Synthesis

A mixture of 2-amino-3-chloro-4-methylpyridine 0.96 g (0. 0067πο1) and benzoic acid, 1.83 g (0.015 mol) was added, the copper powder was added, reacted at 150 ° C for 1 h, and the reaction solution was added to water, Adding the decolorizer, adjusting the pH of the filtered solution to pH 9, filtering and drying the filter cake to obtain 0.65 g of crude 4-Methylpyridin-2-amine as a yellow solid, the yield was 89.3percent. The crude 0.65g dissolved in dilute hydrochloric acid solution to the crude product completely dissolved to obtain a salt solution, adding ethyl acetate to the salt solution to extract the water phase, slowly adding sodium bicarbonate to the aqueous phase Solution to pH 9, the solid was completely precipitated, filtered, and the filtrate was washed with distilled water and dried in vacuo to give 0.53 g of 4-Methylpyridin-2-amine as a pale yellow solid.

Purification Methods

Crystallise it from EtOH or a 2:1 *benzene/acetone mixture, and dry it under vacuum as in the prevous entry. [Beilstein 22/9 V 325.]

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View Lastest Price from 4-Methylpyridin-2-amine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Aminopicoline pictures 2024-04-25 Aminopicoline
695-34-1
US $10.00 / kg 1kg 99.6% 100000 Ouhuang Engineering Materials (Hubei) Co., Ltd
2-Amino-4-Methyl-Pyridin pictures 2023-07-01 2-Amino-4-Methyl-Pyridin
695-34-1
US $5.00-2.00 / KG 1KG 99% 10000kg Hebei Guanlang Biotechnology Co,.LTD
4-Methylpyridin-2-amine pictures 2023-03-03 4-Methylpyridin-2-amine
695-34-1
US $60.00 / kg 1kg 99% 100 tons Hebei Duling International Trade Co. LTD
  • Aminopicoline pictures
  • Aminopicoline
    695-34-1
  • US $10.00 / kg
  • 99.6%
  • Ouhuang Engineering Materials (Hubei) Co., Ltd
2-amino-4-methyl-pyridin 2-amino-4-picolin 2-Amino-gamma-picoline 2-Aminop-4-picoline 2-Pyridinamine,4-methyl- w45 w45raschig 4-METHYL-2-PYRIDYLAMINE 4-METHYLPYRIDIN-2-AMINE 4-METHYL-PYRIDIN-2-YLAMINE AKOS BBS-00004343 AKOS 91145 2-AMINO-4-PICOLINE 2-AMINO-4-METHYLPYRIDINE TIMTEC-BB SBB004354 OTAVA-BB BB7015122364 SODIUM DICHROMATE 2H2O SODIUM DICHROMATE-2-HYDRATE SODIUM DICHROMATE, HYDROUS SODIUM BICHROMATE DIHYDRATE 2-amino-4-picoline;2-Amino-4-methylpyridine AURORA 11319 2-Amino-4-Methylpyridine,Nevirapine 2-Pyridinamine,4-methyl-(9CI) 2-Amio-4-Methylpyridine 2-Amino-4-picoL 2-AMINO-4-METHYL PYRODINE 2-AMINO-4-METHYL PYRIDINE 4-METHYLPYRIDIN-2-YLAMINE 2-Amino-4-methylpyridine, 98+% NSC 1490 NSC 176165 NSC 6972 2-AMINO-4-METHYLPYRIDINE FOR SYNTHESIS 2-Amino-4-methylpyridine ,99% 2-Amino-4-picoline,98% 2-AMino-4-picoline, 98% 100GR 2-Amino-4-picoline, 4-Methylpyridin-2-amine 4M2AP 4-Methyl-2-aminopyridine 4-Methyl-2-pyridamine 4-methyl-2-pyridinamin 4-Methyl-2-pyridinamine 4-Picoline, 2-amino- alpha-Amino-gamma-picoline Aminopicoline Ascensil component of Ascensil component of Askensil Methyl-4 amino-2-pyridine methyl-4amino-2-pyridine Pyridine, 2-amino-4-methyl- RA 1226 ra1226 VMI 20-4 W 45 W 45 Raschig Rifaximin EP Impurity A Rifaximin impurity A (EP)