4-Methylpyridin-2-amine
- CAS No.
- 695-34-1
- Chemical Name:
- 4-Methylpyridin-2-amine
- Synonyms
- 2-AMINO-4-METHYLPYRIDINE;2-AMINO-4-PICOLINE;Aminopicoline;w45;W 45;4M2AP;ra1226;RA 1226;NSC 1490;NSC 6972
- CBNumber:
- CB9854129
- Molecular Formula:
- C6H8N2
- Molecular Weight:
- 108.14
- MDL Number:
- MFCD00149166
- MOL File:
- 695-34-1.mol
- MSDS File:
- SDS
Melting point | 96-99 °C (lit.) |
---|---|
Boiling point | 230 °C (lit.) |
Density | 1.0275 (estimate) |
vapor pressure | 3.71Pa at 25℃ |
refractive index | 1.5560 (estimate) |
Flash point | 118 °C |
storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
solubility | DMF: freely soluble |
form | Flakes |
pka | pK1: 7.48(+1) (25°C) |
color | Slightly yellow to beige or brown |
Water Solubility | SOLUBLE |
Sensitive | Hygroscopic |
Merck | 14,466 |
BRN | 107066 |
LogP | 0.56-1.08 |
CAS DataBase Reference | 695-34-1(CAS DataBase Reference) |
EWG's Food Scores | 1 |
FDA UNII | 394N1Z644H |
NIST Chemistry Reference | 2-Pyridinamine, 4-methyl-(695-34-1) |
EPA Substance Registry System | 2-Pyridinamine, 4-methyl- (695-34-1) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS06,GHS08 |
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Signal word | Danger | |||||||||
Hazard statements | H301+H311+H331-H373 | |||||||||
Precautionary statements | P280-P301+P310+P330-P302+P352+P312-P304+P340+P311-P314 | |||||||||
Hazard Codes | T | |||||||||
Risk Statements | 45-46-60-61-8-21-25-26-34-42/43-48/23-50/53-36/37/38-33-23/24/25 | |||||||||
Safety Statements | 53-45-60-61-37/39-28A-26-36/37/39 | |||||||||
RIDADR | UN 3086 6.1/PG 1 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | TJ5150000 | |||||||||
TSCA | Yes | |||||||||
HazardClass | 6.1 | |||||||||
PackingGroup | II | |||||||||
HS Code | 29333999 | |||||||||
Toxicity | LD50 oral in rat: 200mg/kg | |||||||||
NFPA 704 |
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4-Methylpyridin-2-amine price More Price(37)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 123080 | 2-Amino-4-methylpyridine 99% | 695-34-1 | 100g | $59.9 | 2024-03-01 | Buy |
TCI Chemical | A0402 | 2-Amino-4-methylpyridine >98.0%(GC)(T) | 695-34-1 | 25g | $65 | 2024-03-01 | Buy |
TCI Chemical | A0402 | 2-Amino-4-methylpyridine >98.0%(GC)(T) | 695-34-1 | 500g | $390 | 2024-03-01 | Buy |
Alfa Aesar | A14177 | 2-Amino-4-methylpyridine, 98% | 695-34-1 | 25g | $22.65 | 2024-03-01 | Buy |
Alfa Aesar | A14177 | 2-Amino-4-methylpyridine, 98% | 695-34-1 | 100g | $32.65 | 2024-03-01 | Buy |
4-Methylpyridin-2-amine Chemical Properties,Uses,Production
Chemical Properties
Light yellow to brown flakes
Uses
Intermediate, medicine.
Uses
2-Amino-4-methylpyridine has been used in the synthesis of 2-amino-4-methyl-pyridinium 2-hy-droxy-benzoate. It is potent inhibitor of NOS2 (iNOS) in vitro. It is used as pharmaceutical intermediate.
Synthesis Reference(s)
The Journal of Organic Chemistry, 72, p. 4554, 2007 DOI: 10.1021/jo070189y
General Description
2-Amino-4-methylpyridine acts as ligand and forms methoxo-bridged copper(II) complexes.
Biochem/physiol Actions
2-Amino-4-methylpyridine inhibits the activity of inducible NO synthase isolated from mouse RAW 264.7 cells in vitro.
Synthesis
A mixture of 2-amino-3-chloro-4-methylpyridine 0.96 g (0. 0067πο1) and benzoic acid, 1.83 g (0.015 mol) was added, the copper powder was added, reacted at 150 ° C for 1 h, and the reaction solution was added to water, Adding the decolorizer, adjusting the pH of the filtered solution to pH 9, filtering and drying the filter cake to obtain 0.65 g of crude 4-Methylpyridin-2-amine as a yellow solid, the yield was 89.3percent. The crude 0.65g dissolved in dilute hydrochloric acid solution to the crude product completely dissolved to obtain a salt solution, adding ethyl acetate to the salt solution to extract the water phase, slowly adding sodium bicarbonate to the aqueous phase Solution to pH 9, the solid was completely precipitated, filtered, and the filtrate was washed with distilled water and dried in vacuo to give 0.53 g of 4-Methylpyridin-2-amine as a pale yellow solid.
Purification Methods
Crystallise it from EtOH or a 2:1 *benzene/acetone mixture, and dry it under vacuum as in the prevous entry. [Beilstein 22/9 V 325.]
4-Methylpyridin-2-amine Preparation Products And Raw materials
Raw materials
Preparation Products
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Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Terma Medicare India Pvt.,Ltd | +8613916485955 | shivshanghai@yahoo.com | India | 136 | 58 |
Jinan Dexinjia Bio&Tech Co., Ltd | +86-0531-82375893 +86-15553111391 | sales@jndxj.com | China | 1201 | 58 |
Hebei Guanlang Biotechnology Co,.LTD | +8619930503252 | daisy@crovellbio.com | China | 5962 | 58 |
Ouhuang Engineering Materials (Hubei) Co., Ltd | +8617702722807 | admin@hbouhuang.com | China | 3001 | 58 |
Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 885 | 50 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21689 | 55 |
career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 7019 | 58 |
Hangzhou Cyanochem Co., Ltd. | +86 17788583750 | sales@cyanochem.com | CHINA | 283 | 58 |
View Lastest Price from 4-Methylpyridin-2-amine manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-04-25 | Aminopicoline
695-34-1
|
US $10.00 / kg | 1kg | 99.6% | 100000 | Ouhuang Engineering Materials (Hubei) Co., Ltd | ||
2023-07-01 | 2-Amino-4-Methyl-Pyridin
695-34-1
|
US $5.00-2.00 / KG | 1KG | 99% | 10000kg | Hebei Guanlang Biotechnology Co,.LTD | ||
2023-03-03 | 4-Methylpyridin-2-amine
695-34-1
|
US $60.00 / kg | 1kg | 99% | 100 tons | Hebei Duling International Trade Co. LTD |
- Aminopicoline
695-34-1
- US $10.00 / kg
- 99.6%
- Ouhuang Engineering Materials (Hubei) Co., Ltd
- 2-Amino-4-Methyl-Pyridin
695-34-1
- US $5.00-2.00 / KG
- 99%
- Hebei Guanlang Biotechnology Co,.LTD
- 4-Methylpyridin-2-amine
695-34-1
- US $60.00 / kg
- 99%
- Hebei Duling International Trade Co. LTD
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