ChemicalBook > Product Catalog >Organic Chemistry >Heterocyclic Compounds >Tetrahydrofuran

Tetrahydrofuran

Tetrahydrofuran, the abbreviation of THF, is a heterocyclic organic compound. It belongs to ethers and is the fully hydrogenated product of the aromatic compound furan. It can be used as an aprotic solvent with moderate polarity in chemical reaction and solvent extraction. Tetrahydrofuran is a colorless, low viscosity liquid with a similar smell as ether.
Tetrahydrofuran Suppliers list
Company Name: Shandong Yanshuo Chemical Co., Ltd.
Tel: +86-18678179670 +86-18615116763
Email: sales@yanshuochem.com
Products Intro: Product Name:Tetrahydrofuran
CAS:109-99-9
Purity:99.9% Package:180Kg/Drum;940USD
Company Name: Hefei TNJ Chemical Industry Co.,Ltd.
Tel: +86-0551-65418679 +86-18949832763
Email: info@tnjchem.com
Products Intro: Product Name:Tetrahydrofuran
CAS:109-99-9
Purity:99.99% Package:1KG;2USD
Company Name: Tianjin Zhongxin Chemtech Co., Ltd.
Tel: +86-022-66880623 +8618622897568
Email: sales@tjzxchem.com
Products Intro: Product Name:Tetrahydrofuran
CAS:109-99-9
Purity:99%min Package:180kg drum
Company Name: Shaanxi Didu New Materials Co. Ltd
Tel: +86-89586680 +86-13289823923
Email: 1026@dideu.com
Products Intro: Product Name:Formalin;Tetrahydrofuran
CAS:109-99-9
Purity:0.99 Package:25KG,200L
Company Name: Zouping mingyuan import & export trading co., ltd
Tel: +86-0543-2240078 +8618364991597
Email: myzhao793@163.com
Products Intro: Product Name:Tetrahydrofuran
CAS:109-99-9
Purity:99.9% Package:25KG;USD

Tetrahydrofuran manufacturers

  • Tetrahydrofuran
  • Tetrahydrofuran pictures
  • $1.00 / 1g
  • 2024-05-21
  • CAS:109-99-9
  • Min. Order: 1g
  • Purity: 99%
  • Supply Ability: 20 Tons
  • Tetrahydrofuran
  • Tetrahydrofuran pictures
  • $36.00 / 1kg
  • 2024-05-17
  • CAS:109-99-9
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 300tons
  • Tetrahydrofuran
  • Tetrahydrofuran pictures
  • $145.00 / 10Barrels
  • 2024-05-17
  • CAS:109-99-9
  • Min. Order: 10Barrels
  • Purity: 99.99%
  • Supply Ability: 100Tons

Related articles

Tetrahydrofuran Basic information
Product Name:Tetrahydrofuran
Synonyms:TETRAMETHYLENE ETHER GLYCOL 2000 POLYMER;Tetrahydrofuran ,99.8% [Tetrahydrofuran,ACS/HPLC Certified];Tetrahydrofuran, 99.6%, stabilized with BHT, for analysis ACS;Tetrahydrofuran, 99+%, stabilized with BHT, extra pure;Tetrahydrofuran, 99.9%, anhydrous, stabilized, extra pure;Tetrahydrofuran, 99.5+%, for spectroscopy;Tetrahydrofuran, 99.8%, unstabilized, for HPLC;Tetrahydrofuran, 99.85%, water <50 ppm, stabilized, extra dry
CAS:109-99-9
MF:C4H8O
MW:72.11
EINECS:203-726-8
Product Categories:Pharmaceutical intermediates;Pharmaceutical intermediate and medicine grade;Chemistry;Biotech;Biotech Solvents;Products;Returnable Containers;Sure/Seal Bottles;PVC Coated Bottles;Alternative Energy;Anhydrous;Electrolytes;Materials Science;Analytical Reagents;Anhydrous Solvents;Synthetic Organic Chemistry;Solvent Bottles;Solvent by Application;Solvent by Type;Solvent Packaging Options;Solvents;ReagentPlus;ReagentPlus Solvent Grade Products;NMR;Analytical/Chromatography;CHROMASOLV Plus;Chromatography Reagents &;HPLC &;HPLC Plus Grade Solvents (CHROMASOLV);HPLC/UHPLC Solvents (CHROMASOLV);Tetrahydrofuran (THF);ACS and Reagent Grade Solvents;ACS Grade;ACS Grade Solvents;Amber Glass Bottles;Carbon Steel Cans with NPT Threads;Closed Head Drums;Drums Product Line;Semi-Bulk Solvents;Spectrophotometric Solvents;Spectroscopy Solvents (IR;UV/Vis);Histological;Core Bioreagents;Histological Solvents;Life Science Reagents for Immunohistochemistry (IHC);Organic Solvents;Research Essentials;NOWPak Products;UHPLC Solvents (CHROMASOLV);Analytical Reagents for General Use;Puriss p.a.;T-Z;Pyridines ,Halogenated Heterocycles;research chemical;109-99-9;bc0001;TCI
Mol File:109-99-9.mol
Tetrahydrofuran Structure
Tetrahydrofuran Chemical Properties
Melting point -108°C
Boiling point 66 °C
density 0.887 g/mL at 20 °C
vapor density 2.5 (vs air)
vapor pressure <0.01 mm Hg ( 25 °C)
refractive index n20/D 1.465
Fp >230 °F
storage temp. Store at +5°C to +30°C.
solubility water: soluble
form Liquid
Specific Gravity0.89
color <10(APHA)
Relative polarity0.207
PH7-8 (200g/l, H2O, 20℃)
OdorEthereal, detectable at 2 to 50 ppm
PH Range7
explosive limit1.5-12.4%(V)
Water Solubility miscible
FreezingPoint -108℃
Sensitive Air Sensitive & Hygroscopic
λmaxλ: 245 nm Amax: ≤0.26
λ: 275 nm Amax: ≤0.046
λ: 315 μm Amax: ≤0.0044
Merck 14,9211
BRN 102391
Henry's Law Constant1.54 (static headspace-GC, Welke et al., 1998)
Exposure limitsTLV-TWA 200 ppm (590 mg/m3) (ACGIH, MSHA, and OSHA); STEL 250 ppm (ACGIH); IDLH 20,000 ppm (NIOSH).
Dielectric constant7.5800000000000001
Dielectric constant11.6(-70℃)
Stability:Stable. Incompatible with halogens, strong oxidizing agents, strong reducing agents, strong bases, oxygen. May generate explosive peroxides in storage if in contact with air. Highly flammable. Store at room temperature under nitrogen. Hazardous polymerisation may occur. Light sensitive. May contain 2,6-di-tertbutyl-4-methylphenol (BHT) as a s
InChIKeyWYURNTSHIVDZCO-UHFFFAOYSA-N
LogP0.45 at 25℃
CAS DataBase Reference109-99-9(CAS DataBase Reference)
NIST Chemistry ReferenceFuran, tetrahydro-(109-99-9)
IARC2B (Vol. 119) 2019
EPA Substance Registry SystemTetrahydrofuran (109-99-9)
Safety Information
Hazard Codes Xi,F,Xn
Risk Statements 36/37/38-36/37-19-11-40
Safety Statements 26-36-33-29-16-46-37-13
RIDADR UN 2924 3/PG 2
WGK Germany 1
RTECS MD0916000
3-10-23
Autoignition Temperature610 °F
TSCA Yes
HazardClass 3
PackingGroup II
HS Code 29321100
Hazardous Substances Data109-99-9(Hazardous Substances Data)
ToxicityLD50 oral (rat) 2880 mg/kg
LC50 inhal (rat) 21,000 ppm (3 h)
PEL (OSHA) 200 ppm (590 mg/m3)
TLV-TWA (ACGIH) 200 ppm (590 mg/m3)
STEL (ACGIH) 250 ppm (737 mg/m3)
IDLA2,000 ppm [10% LEL]
MSDS Information
ProviderLanguage
1,4-Epoxybutane English
SigmaAldrich English
Tetrahydrofuran Usage And Synthesis
DescriptionTetrahydrofuran (THF) is a colorless, volatile liquid with an ethereal or acetonelike smell and is miscible in water and most organic solvents.It is highly flammable and may thermally decompose to carbon monoxide and carbon dioxide. Prolonged storage in contact with air and in the absence of an antioxidant may cause THF to decompose into explosive peroxides.
Tetrahydrofuran
Tetrahydrofuran is used in the manufacture of polymers as well as agricultural, pharmaceutical, and commodity chemicals. Manufacturing activities commonly occur in closed systems or under engineering controls that limit worker exposure and release to the environment. THF is also used as a solvent (e.g., pipe fitting) that may result in more significant exposures when used in confined spaces without sufficient ventilation. Although THF is naturally present in coffee aroma, floured chickpeas, and cooked chicken, natural exposures are not anticipated to pose a significant hazard.
DescriptionTHF (Tetrahydrofuran) is a stable compound with relatively low boiling point and excellent solvency. It is widely-used for dissolution and reaction of various substances. Also it is used as a starting material for the synthesis of poly(tetramethylene ether) glycol (PTMG), etc. Since 1982, Mitsubishi Chemical's Yokkaichi plant has produced high-purity, high-quality THF from butadiene using our proprietary technology. CAS: No. 109-99-9 (T) EINECS: No. 203-726-8 Japan, Chemical Substances Control Law: METI-No. 5-53 Japan, Industrial Safety and Health Law: No. 5-53, ID No. 367 (SDS required) Japan, Poisonous and Deleterious Substances Control Law: Not applicable. Japan, Fire Services Law: Hazardous Material Class 4 Petroleums No.1 (water-soluble liquid). Hazardous Rank II U.N. Class: 3  U.N. No.: UN2056
Chemical PropertiesTetrahydrofuran (THF) is an industrial solvent widely recognized for its unique combination of useful properties. DuPont THF is better than 99.9% pure with a small (0.025-0.040 wt % ) amount of butylated hydroxytoluene (BHT, 4-methyl-2,6-di-tertbutyl phenol) added as an antioxidant. Tetrahydrofuran is a cycloaliphatic ether and is not "photochemically reactive" as defined in Section k of Los Angeles County's Rule 66 (equivalent to Rule 442 of the Southern California Air Pollution Control District). THF has an ethereal odor. The Odor Threshold is listed @ 3.8 (3M), 20-50ppm, and 31ppm. It is also a common laboratory reagent and an intermediate in chemical syntheses of consumer and industrial products such as nutritionals, pharmaceuticals, and insecticides (HSDB, 2011).
Physical propertiesTetrahydrofuran is a clear, colourless liquid with a strong ether-like odour. Odor threshold concentration is 2 ppm (quoted, Amoore and Hautala, 1983). It is highly flammable. Contact of tetrahydrofuran with strong oxidising agents may cause explosions. Tetrahydrofuran may polymerise in the presence of cationic initiators. Contact with lithium–aluminium hydride, with other lithium–aluminium alloys, or with sodium or potassium hydroxide can be hazardous.
UsesSolvent for high polymers, especially polyvinyl chloride. As reaction medium for Grignard and metal hydride reactions. In the synthesis of butyrolactone, succinic acid, 1,4-butanediol diacetate. Solvent in histological techniques. May be used under Federal Food, Drug & Cosmetic Act for fabrication of articles for packaging, transporting, or storing of foods if residual amount does not exceed 1.5% of the film: Fed. Regist. 27, 3919 (Apr. 25, 1962).
UsesButylene oxide is used as a fumigant and inadmixture with other compounds. It is usedto stabilize fuel with respect to color andsludge formation.
UsesTetrahydrofuran is used primarily (80%) to make polytetramethylene ether glycol, the base polymer used primarily in the manufacture of elastomeric fibers (e.g., spandex) as well as polyurethane and polyester elastomers (e.g., artificial leather, skateboard wheels). The remainder (20%) is used in solvent applications (e.g., pipe cements, adhesives, printing inks, and magnetic tape) and as a reaction solvent in chemical and pharmaceutical syntheses.
UsesTetrahydrofuran is used as a solvent forresins, vinyls, and high polymers; as a Grignardreaction medium for organometallic,and metal hydride reactions; and in the synthesisof succinic acid and butyrolactone.
DefinitionChEBI: A cyclic ether that is butane in which one hydrogen from each methyl group is substituted by an oxygen.
General DescriptionA clear colorless liquid with an ethereal odor. Less dense than water.Flash point 6°F. Vapors are heavier than air.
Air & Water ReactionsHighly flammable. Oxidizes readily in air to form unstable peroxides that may explode spontaneously [Bretherick, 1979 p.151-154, 164]. Soluble in water.
Reactivity ProfileTetrahydrofuran reacts violently with oxidizing agents leading to fires and explosions [Handling Chemicals Safely 1980. p. 891]. Subject to peroxidation in the air. Peroxides or their products react exothermically with lithium aluminum hydride [MCA Guide for Safety 1973]. Thus, use as a solvent for lithium aluminum hydride has led to fires. Using potassium hydroxide or sodium hydroxide to dry impure Tetrahydrofuran that contains peroxides has resulted in explosions. A violent explosion occurred during the preparation of sodium aluminum hydride from sodium and aluminum in a medium of Tetrahydrofuran [Chem. Eng. News 39(40):57. 1961]. THF forms explosive products with 2-aminophenol [Lewis 3227].
Health HazardThe toxicity of tetrahydrofuran is of loworder in animals and humans. The targetorgans are primarily the respiratory systemand central nervous system. It is an irritantto the upper respiratory tract and eyes.At high concentrations it exhibits anestheticproperties similar to those of many loweraliphatic ethers. Exposure to concentrationsabove 25,000 ppm in air can cause anesthesiain humans. Other effects noted were strongrespiratory stimulation and fall in bloodpressure (ACGIH 1986). Kidney and liverinjuries occurred in experimental animalsexposed to 3000 ppm for 8 hours/day for20 days (Lehman and Flury 1943). Inhalationof high concentrations of vapors or ingestionof the liquid also causes nausea, vomiting,and severe headache. The acute oraltoxicity is low; the LD50 value in rats is in therange of 2800 mg/kg. The inhalation LC50value in rats is 21,000 ppm/3 h.
Flammability and ExplosibilityTHF is extremely flammable (NFPA rating = 3), and its vapor can travel a considerable distance to an ignition source and "flash back." A 5% solution of THF in water is flammable. THF vapor forms explosive mixtures with air at concentrations of 2 to 12% (by volume). Carbon dioxide or dry chemical extinguishers should be used for THF fires.
THF can form shock- and heat-sensitive peroxides, which may explode on concentration by distillation or evaporation. Always test samples of THF for the presence of peroxides before distilling or allowing to evaporate. THF should never be distilled to dryness.
Chemical ReactivityReactivity with Water No reaction; Reactivity with Common Materials: No data; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: May occur when the product is in contact with strong acids and bases; Inhibitor of Polymerization: No data.
Industrial usesTetrahydrofuran (THF), the saturated derivative of furan, when used as a solvent for high molecular weight polyvinyl chloride (PVC), vinyl chloride copolymers, and polyvinylidene chloride copolymers at ambient temperatures yields solutions of high solids content. Blends of THF and methyl ethyl ketone are often used for increased solvency in certain polymer compositions. Applications for THF polymer solutions include PVC top coatings of automotive upholstery, audio tape coatings of polyurethane/metal oxides on polyester tape, polyurethane coatings for fabric finishes, water-vapor barrier film coatings of PVC, and polyvinylidene chloride copolymers onto cellophane film. Tetrahydrofuran is an excellent solvent for many inks used for printing on PVC film and on PVC plastic articles. Polyvinyl chloride pipe welding cements are made by dissolving the resin in THF solvent. Other adhesive applications include cements for leather, plastic sheeting, and for molded plastic assemblies. Other uses of THF are as a chemical intermediate and as a complexing solvent for various inorganic, organometallic, and organic compounds. These THF complexes are important as Grignard reagents, catalysts for organic reactions, and in stereo-specific polymerizations. Tetrahydrofuran is the solvent of choice in many pharmaceutical reactions and applications. The excellent solvency of THF makes this solvent ideal for solvent cleaning of polymer manufacturing and processing equipment.
Safety ProfileModerately toxic by ingestion and intraperitoneal routes. Mildly toxic by inhalation. Human systemic effects by inhalation: general anesthesia. Mutation data reported. Irritant to eyes and mucous membranes. Narcotic in high concentrations. Reported as causing injury to liver and kidneys. Flammable liquid. A very dangerous fire hazard when exposed to heat, flames, oxidizers. Explosive in the form of vapor when exposed to heat or flame. In common with ethers, unstabilized tetrahydrofuran forms thermally explosive peroxides on exposure to air. Stored THF must always be tested for peroxide prior to distdlation. Peroxides can be removed by treatment with strong ferrous sulfate solution made slightly acidic with sodium bisulfate. Caustic alkalies deplete the inhibitor in THF and may subsequently cause an explosive reaction. Explosive reaction with KOH, NaAlH2, NaOH, sodium tetrahydroaluminate. Reacts with 2-aminophenol + potassium dioxide to form an explosive product. Reacts with lithium tetrahydroaluminate or borane to form explosive hydrogen gas. Violent reaction with metal halides (e.g., hafnium tetrachloride, titanium tetrachloride, zirconium tetrachloride). Vigorous reaction with bromine, calcium hydride + heat. Can react with oxidizing materials. To fight fire, use foam, dry chemical, COa. When heated to decomposition it emits acrid smoke and irritating fumes. See also 2TETRAHYDROFURYL HYDROPEROXIDE
Potential ExposureThe primary use of tetrahydrofuran is as a solvent to dissolve synthetic resins, particularly polyvinyl chloride and vinylidene chloride copolymers. It is also used to cast polyvinyl chloride films, to coat substrates with vinyl and vinylidene chloride; and to solubilize adhesives based on or containing polyvinyl chloride resins. A second large market for THF is as an electrolytic solvent in the Grignard reaction-based production of tetramethyl lead. THF is used as an intermediate in the production of polytetramethylene glycol.
CarcinogenicityTHF showed little evidence of mutagenic activity in a variety of in vitro and in vivo assays.
SourceLeaches from PVC cement used to join tubing (Wang and Bricker, 1979)
storageTHF should be used only in areas free of ignition sources, and quantities greater than 1 liter should be stored in tightly sealed metal containers in areas separate from oxidizers. Containers of THF should be dated when opened and tested periodically for the presence of peroxides.
ShippingUN2056 Tetrahydrofuran, Hazard Class: 3; Labels: 3-Flammable liquid.
Purification MethodsIt is obtained commercially by catalytic hydrogenation of furan from pentosan-containing agricultural residues. It was purified by refluxing with, and distilling from LiAlH4 which removes water, peroxides, inhibitors and other impurities [Jaeger et al. J Am Chem Soc 101 717 1979]. Peroxides can also be removed by passage through a column of activated alumina, or by treatment with aqueous ferrous sulfate and sodium bisulfate, followed by solid KOH. In both cases, the solvent is then dried and fractionally distilled from sodium. Lithium wire or vigorously stirred molten potassium have also been used for this purpose. CaH2 has also been used as a drying agent. Several methods are available for obtaining the solvent almost anhydrous. Ware [J Am Chem Soc 83 1296 1961] dried it vigorously with sodium-potassium alloy until a characteristic blue colour was evident in the solvent at Dry-ice/cellosolve temperatures. The solvent is kept in contact with the alloy until distilled for use. Worsfold and Bywater [J Chem Soc 5234 1960], after refluxing and distilling from P2O5 and KOH, in turn, refluxed the solvent with sodium-potassium alloy and fluorenone until the green colour of the disodium salt of fluorenone was well established. [Alternatively, instead of fluorenone, benzophenone, which forms a blue ketyl, can be used.] The tetrahydrofuran was then fractionally distilled, degassed and stored above CaH2. p-Cresol or hydroquinone inhibit peroxide formation. The method described by Coetzee and Chang [Pure Appl Chem 57 633 1985] for 1,4-dioxane also applies here. Distillations should always be done in the presence of a reducing agent, e.g. FeSO4. [Beilstein 17 H 10, 17 I 5, 17 II 15, 17 III/IV 24, 17/1 V 27.] It irritates the skin, eyes and mucous membranes, and the vapour should never be inhaled. It is HIGHLY FLAMMABLE, and the necessary precautions should be taken. Rapid purification: Purification as for diethyl ether.
Toxicity evaluationThe principal target organs in rodents receiving repeated exposures to THF are the central nervous system (CNS), kidney, and liver. The CNS effects caused by THF are thought to be mediated via the THF metabolites tetrahydro-2-furanone and 4-hydroxybutanoic acid. This is consistent with the CNS effects associated with these metabolites as well as the higher narcotic potency of THF in mice than in comparably exposed rats and the shorter half-life of THF in the presence of mouse versus rat hepatic microsomes. In contrast to the CNS effects, the male rat kidney tumors and female mouse liver tumors appear to be induced by the parent compound, not a metabolite. Lifetime exposures of rodents to tetrahydro-2-furanone, 4-hydroxybutanoic acid, and sodium succinate have not resulted in treatment-related carcinogenic effects, and a mechanistic study demonstrated that hepatocellular proliferation in female mice exposed to THF is actually enhanced by CYP450 inhibition, not decreased as one would predict if proliferation is mediated by a THF metabolite. The THF database has been reviewed against potential mode of action (MoA) candidates including direct DNA reactivity, cytotoxicity followed by regenerative cell proliferation, excessive accumulation of alpha 2u-globulin, exacerbation of rat chronic progressive nephropathy (CPN), and nuclear receptor (e.g., constitutive androstane receptor) activation leading to enzyme induction and enhanced cell proliferation. While the tumorigenic MoAs have not been identified, exacerbation of CPN (rat kidney) and nuclear receptor activation (mouse liver) are currently the more favored. BothMoAs are thought to involve nongenotoxic (i.e., threshold) events. CPN has no known counterpart in humans.
IncompatibilitiesForms thermally explosive peroxides in air on standing (in absence of inhibitors). Peroxides can be detonated by heating, friction, or impact. Reacts violently with strong oxidizers, strong bases and some metal halides. Attacks some forms of plastics, rubber and coatings.
Waste DisposalConsult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Concentrated waste containing peroxides-perforation of a container of the waste from a safe distance followed by open burning.
Tag:Tetrahydrofuran(109-99-9) Related Product Information
1,3-Cyclopentadiene 1,4-Butanediol Magnesium oxide Zinc oxide Propylene oxide Cuprous oxide ETHYLENE OXIDE Iron oxide NITRIC OXIDE Methyl cyclopentenolone 1-BUTENE Cyclopentene METHYLCYCLOPENTADIENE DIMER Tetrahydrofurfuryl alcohol Poly(tetrahydrofuran) TETRAHYDROFURAN-2-ACETIC ACID ETHYL ESTER TETRAHYDROFURAN-3-CARBOXALDEHYDE 98 Tetrahydrofurfuryl acrylate